March, 2025 : Celebrating and bidding a heartfelt farewell to our great Lindsay Osso with lots of good memories, cheers, and gratitude. We wish you the very best in your future , knowing you will do amazing!
March 2025: Our Master's Student Abigail Kucera presenting her work on OPC's aged mice presented at the AAA. Great work!
Lindsay's farewell celebration!
We will miss you
March 2025: Celebrating Clara's birthday
March 11, 2025: Kristen Schuster giving a fantastic presentation at the Glia Research Gordon in Ventura, California 2025! Michael Stockton selected to speak at the GRS 2025.
March 11, 2025: Michael Stockton selected to speak at the GRS 2025.
March 2025: the google eye caper strikes! Who could it have been?
Kristen at the GRC discussing calcium's role in myelin dynamics
February 2025: Our amazing undergraduate researcher Stephanie Karas was awarded the Eureca grant! Very well deserved!
February 3rd. 2025: Our undergraduate researcher, Kate Brassell was featured in a University news discussing the ISCORE program. So well deserved for your motivation and dedication!
Michael S. poster session at the GRS
January 31st, 2025: Hughes-Welle MPI RO1 Renewal
Gustavo and Kate at the ISCORE presentation
January 16th, 2025: Congratulations Gustavo Della-Flores Nunes and Lindsay in collaboration with with Daniel Denman and the Autobahn manuscript is online and officially published at Nature Communications, read it here:
January 3rd, 2025 : Exciting News, Dr. Maureen Wentling has joined our lab as a postdoctoral fellow. Great to have you on the team!
January 3rd, 2025 : Huge congratulations to Michael Stockton for submitting his manuscript today! Wohoo!
December 3, 2025: Gustavo Della Flora Nunes and Lindsay Osso's Bautobahn manuscript has been accepted in principle at Nature Communications!!!
Welcoming drinks for Maureen
November 2025: Gustavo gave an excellent talk at the Tykeson Conference ! Nailed a lot of great questions!
Yessenia presenting her first poster at NSP 2024
October 20, 2025: Yessenia Mancha Corchado won the first place at the poster session at the Neuroscience Retreat Program! Way to go Yessenia!
October 2025 : Hughes Lab celebrating Michael Thornton's time in the lab and exciting next adventures! Thank you Michael for everything; we are honored, proud, excited, and grateful that you shared your Ph.D journey and Postdoc with us!!!
September 2024 : We're ecstatic to have Clara Mutschler join us as a post doctoral fellow
August 20, 2024 : Gustavo, Lindsay, and Kristen representing at the Cold Spring Harbor Glia
Farewell Gathering to Michael Thornton
August 20, 2024 : Congratulations Kristen Schuster for passing your comps with flying colors! Exceptional!
August 2024 : Congratulations to Stephanie Karas and Kate Brassell for both being awarded Eureka grants!! We are lucky to work with such talented folks!
Kristen, Gustavo, and Lindsay presenting their research at CSHL Glia, 2024
July 26th, 2024 : Kate and Stephanie presenting their poster at the NSP CORE program! We're so proud of you both!
June 3rd, 2024 : Welcome undergraduate Stephanie Karas! We are excited to have you in the lab with the CORE-Immuno Summer Experience
Kate at her NSP CORE poster
April 2024: Congratulations to Kristen Schuster for being accepted into the Advanced Techniques in Molecular Neuroscience course at CSHL!!!!
March 18th, 2024: Fantastic talk Michael S, presenting at the Myelin GRS
Stephanie at her NSP CORE Poster
March 15th 2024: Undergraduate researcher Kate Brassell joins our lab as part of the ISCORE program! Glad to have you!
Michael presenting at Myelin GRS
February 2024: Woohoo! Lab Celebration! Big Congratulations to Gustavo Della-Flores Nunes and Lindsay's in NC paper, Michael Thornton's accepted Nature Neuroscience Paper, our new rotation students, plus more! We're crushing it!
Whole team together!
February 2024: Starting the year stronger than ever with this new preprint paper, led by Gustavo Della-Flores Nunes and Lindsay Osso, and in collaboration with the Denman lab and Autobahn Therapeutics. This paper dives deep into myelin repair, remyelination therapies, and neural function. Check out the pre-print here!
The Lab celebrating the Autobahn paper submission! Cheers!
December 19, 2024 : Congratulations Lindsay Osso, Nature Neuroscience has accepted our review on pre-existing myelin dynamics!!
November, 2023 : Michael's Thornton paper "Long-term in vivo three-photon imaging reveals region-specific differences in healthy and regenerative oligodendrogenesis." is accepted in principle at Nature Neuroscience read the pre-print version here!
Submission success !
November, 2023 : Michael's Stockon presenting his fascinating data and thesis project regarding the dynamics of OPC's quiescence survival and demyelination during 2023 Society for Neuroscience Conference! Amazing work Michael!
October, 20 2023 : Rongchen from the Welle Lab, and Lindsay present current research and advances to MS patients NMSS Myelin Tour
Michael showing his research at 2023 Society for Neuroscience Conference
October 6, 2023 : A heartfelt and big congratulations goes to Michael Thornton for his successful thesis defense!
October, 2023 : We eagerly welcome our new lab member to our team, Yessenia Mancha! We're excited to have you join us!
August, 2023 : Kristen Schuster has been awarded a competitive slot on Neuroscience T32 Training Grant. Congratulations!
Rongchen and Lindsay Presenting their research to MS patients and donors
July, 2023 : We are excited to welcome Kristen Schuster to the lab for her thesis work! Welcome to the team!
July, 2023: Michael T. organized "Special Trainee Symposium" at Euroglia 2023.
July, 2023: New Lab R01! Our project is entitled "in-vivo three photon microscopy of the cortical gray and white matter"
Lab Celebrating Michael's Thesis Defense
April, 2023 : Ecstatic to announce Dr. Lindsay Osso has been awarded the National MS Society Post Doctoral Fellowship and the Department of Defense Multiple Sclerosis Research Program Early Investigator Research Award.
Dr. Michael Thornton
March 9th, 2023 : Congratulations to Ethan Hughes, for being selected as Co-Chair of the 2027 Gordon Research Conference on Glial Biology: Functional Interactions Among Glia and Neurons.
February, 2023 : Dr. Gustavo Della-Flora Nunes has been awarded the IMSVISUAL Symposium Travel Grant, The National MS Society Travel Grant, and the ACTRIMS FORUM 2023 Educational Grant. Amazing job! Congratulations Gustavo!
Michael Thornton Thesis Defense Presentation
Alex at PennPrep!
July 1st, 2022: Gustavo has been awarded a 3 year post-doctoral fellowship from the National Multiple Sclerosis Society.
June 27th, 2022: Congratulations to Ethan on the promotion to Associate Professor with Tenure.
June 10th, 2022: Check out our new paper "Motor Learning Drives Dynamic Patterns of Intermittent Myelination on Learning-activated Axons" on bioRxiv. You can read it here.
May, 2022: Undergraduate researcher Alex Ramirez graduates as a Gardner scholar and is off to PennPrep to do more research! Congrats Alex.
May, 2022: Ethan and Michael present new 3-photon work at the Myelin Gordon Conference in Italy!
Alex presenting her research.
Ethan presenting at Myelin Gordon
Michael's 3P poster at Myelin Gordon Conference
March 19, 2022: Our first Optics paper has been published in The Journal of Neurophotonics. Great work characterizing fluorescent reporters for simultaneous dual-color 3-photon imaging. You can read it here.
November 30, 2021: Michael Stockton passed his comprehensive exam today! Congrats to the Hughes lab's newest PhD Candidate.
September 2, 2021: What a year! The Hughes lab welcomes two new Postdoctoral Researchers - Gustavo Della Flora Nunes and Lindsay Osso, a Masters Student - Johana Haynes, a Professional Research Assistant - Lauren Conant, and a Undergraduate Researcher - Alex Ramirez. We're going to need more space!
July 21th, 2021: Check out our new review article from Michael Stockton and Ethan Hughes reviewing Premyelinating Oligodendrocytes in Frontiers in Cell and Developmental Biology. You can read it here.
May 18th, 2020: Woohoo! First paper from the lab is published online @NatureNeuro! You can read it here.
April 29th, 2020: We are excited to welcome Michael Stockton to the lab for his thesis work!
Cheers to the first beers of summer!
The lab celebrating another successful comps exam.
April 13th, 2020: Congratulations to our own surgeon extraordinaire, Helena Barr, for deciding to join Harvard University's PhD Program in Neuroscience Class of 2020!
April 11th, 2020: Our first review from the lab is now published! Great job Michael Thornton putting this together, lots of cool ideas. You can read the review here.
March 2nd, 2020: Our first manuscript out of the lab has been accepted! You can read the pre-print here. Let the celebrations begin with some mad sabering skills!
February 18th, 2020: Congratulations to Courtney Dobrott for a highly successful rotation and a great rotation talk entitled "Cholinergic signaling as a mechanism for regional oligodendrogenesis during motor learning."
January 29th, 2020: Very excited about the lab's first pre-print on bioRXiv! You can read the pre-print here.
Congrats Michael on passing comps!
Summer student Alejandra showing off her research!
Turns out you can saber bottles with a spoon.
Cheers to a successful month of science in January 2020!
January 23rd, 2020: Exciting news, we got our first R01! Our project entitled "The role of myelination in cortical circuit function and motor behavior" will be conducted in conjunction with the Welle lab.
November 15th, 2019: Hughes Lab served some fresh data at the Neuroscience Program Retreat in Keystone this year! Clara and Helena presented posters on the effects of motor learning on oligodendrocyte lineage cells, Michael showed some great data on new approaches to multi-photon imaging, and Dailey presented her work characterizing population-level changes in neuronal activity throughout de- and re-myelination. Finally, Ethan gave a talk on surviving oligodendrocytes that participate in remyelination.
November 12th, 2019: Congratulations to Michael Stockton and Ian Purvis for their hard work in the lab and their great rotation talks entitled "Oligodendrocyte integration during motor learning" and "Oligodendrocyte precursor cell dynamics in a novel mouse model of MS."
October 20th, 2019: Great minisymposium on myelin degeneration and remyelination at the 2019 Society for Neuroscience Meeting. Ethan presented our recent finding that mature oligodendrocytes that survive demyelination can participate in remyelination.
October 12th, 2019: Congrats to Michael for passing his Comprehensive Exam. His fantastic talk drew a huge crowd!
October 1st, 2019: The Mouse Master himself Anthony Chavez has joined the lab as a full-time PRA. Thrilled to have him on board!
August 4th, 2019: Ethan, Clara, Dailey, and Helena all presented different pieces of our gigantic project at the International Society for Neurochemistry Meeting in Montreal, Quebec. Highlights include that mature oligodendrocytes can contribute to remyelination, that motor learning can stimulate remyelination by new and surviving oligodendrocytes, and that demyelination induces neuronal hyperexcitability in motor cortex!
Golden hour in Keystone for the NSP retreat.
April 27th, 2019: Clara and Helena won awards for Best Poster Presentations at the 2019 Rocky Mountain Regional Neuroscience group meeting in Denver, CO! Their back-to-back posters gave a full recap of how motor learning modulates oligodendrogenesis from the population to single-sheath level in health and disease.
Michael passed his comps! #FirstGradStudent
The team made it to Montreal!
Ask us how we ended up stranded at Time's Square