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Alex at PennPrep!


Alex presenting her research.


Ethan presenting at Myelin Gordon


Michael's 3P poster at Myelin Gordon Conference


Cheers to the first beers of summer!


The lab celebrating another successful comps exam.


Congrats Michael on passing comps!


Summer student Alejandra showing off her research!


Turns out you can saber bottles with a spoon.


Cheers to a successful month of science in January 2020!


Golden hour in Keystone for the NSP retreat.


Michael passed his comps! #FirstGradStudent


The team made it to Montreal!


Ask us how we ended up stranded at Time's Square

July 1st, 2022: Gustavo has been awarded a 3 year post-doctoral fellowship from the National Multiple Sclerosis Society. 

June 27th, 2022: Congratulations to Ethan on the promotion to Associate Professor.

June 10th, 2022: Check out our new paper "Motor Learning Drives Dynamic Patterns of Intermittent Myelination on Learning-activated Axons" on bioRxiv. You can read it here.

May, 2022: Undergraduate researcher Alex Ramirez graduates as a Gardner scholar and is off to PennPrep to do more research! Congrats Alex. 

May, 2022: Ethan and Michael present new 3-photon work at the Myelin Gordon Conference in Italy! 

March 19, 2022: Our first Optics paper has been published in The Journal of Neurophotonics. Great work characterizing fluorescent reporters for simultaneous dual-color 3-photon imaging. You can read it here.

November 30, 2021: Michael Stockton passed his comprehensive exam today! Congrats to the Hughes lab's newest PhD Candidate.

September 2, 2021: What a year! The Hughes lab welcomes two new Postdoctoral Researchers - Gustavo Della Flora Nunes and Lindsay Osso, a Masters Student - Johana Haynes, a Professional Research Assistant - Lauren Conant, and a Undergraduate Researcher - Alex Ramirez. We're going to need more space!

July 21th, 2021: Check out our new review article from Michael Stockton and Ethan Hughes reviewing Premyelinating Oligodendrocytes in Frontiers in Cell and Developmental Biology. You can read it here.

May 18th, 2020: Woohoo! First paper from the lab is published online @NatureNeuro! You can read it here

April 29th, 2020: We are excited to welcome Michael Stockton to the lab for his thesis work!  

April 13th, 2020: Congratulations to our own surgeon extraordinaire, Helena Barr, for deciding to join Harvard University's PhD Program in Neuroscience Class of 2020!

April 11th, 2020: Our first review from the lab is now published! Great job Michael Thornton putting this together, lots of cool ideas. You can read the review here.  

March 2nd, 2020: Our first manuscript out of the lab has been accepted! You can read the pre-print here.  Let the celebrations begin with some mad sabering skills! 

February 18th, 2020: Congratulations to Courtney Dobrott for a highly successful rotation and a great rotation talk entitled "Cholinergic signaling as a mechanism for regional oligodendrogenesis during motor learning."

January 29th, 2020: Very excited about the lab's first pre-print on bioRXiv! You can read the pre-print here.  

January 23rd, 2020: Exciting news, we got our first R01!  Our project entitled "The role of myelination in cortical circuit function and motor behavior" will be conducted in conjunction with the Welle lab

November 15th, 2019: Hughes Lab served some fresh data at the Neuroscience Program Retreat in Keystone this year! Clara and Helena presented posters on the effects of motor learning on oligodendrocyte lineage cells, Michael showed some great data on new approaches to multi-photon imaging, and Dailey presented her work characterizing population-level changes in neuronal activity throughout de- and re-myelination. Finally, Ethan gave a talk on surviving oligodendrocytes that participate in remyelination. 

November 12th, 2019: Congratulations to Michael Stockton and Ian Purvis for their hard work in the lab and their great rotation talks entitled "Oligodendrocyte integration during motor learning" and "Oligodendrocyte precursor cell dynamics in a novel mouse model of MS."

October 20th, 2019: Great minisymposium on myelin degeneration and remyelination at the 2019 Society for Neuroscience Meeting. Ethan presented our recent finding that mature oligodendrocytes that survive demyelination can participate in remyelination. 

October 12th, 2019: Congrats to Michael for passing his Comprehensive Exam. His fantastic talk drew a huge crowd! 

October 1st, 2019: The Mouse Master himself Anthony Chavez has joined the lab as a full-time PRA. Thrilled to have him on board!

August 4th, 2019: Ethan, Clara, Dailey, and Helena all presented different pieces of our gigantic project at the International Society for Neurochemistry Meeting in Montreal, Quebec. Highlights include that mature oligodendrocytes can contribute to remyelination, that motor learning can stimulate remyelination by new and surviving oligodendrocytes, and that demyelination induces neuronal hyperexcitability in motor cortex! 

April 27th, 2019: Clara and Helena won awards for Best Poster Presentations at the 2019 Rocky Mountain Regional Neuroscience group meeting in Denver, CO! Their back-to-back posters gave a full recap of how motor learning modulates oligodendrogenesis from the population to single-sheath level in health and disease.

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